Bovine Pancreatic Trypsin Inhibitor Bpti / Kallikrein Inhibitor CAS No 9087-70-1 Aprotinin

Product Details
Customization: Available
Certification: QS, GMP
Shape: Powder
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Number of Employees
87
Year of Establishment
2014-08-13
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Basic Info.

Type
Trypsin
Function
Inhibit Trypsin, Chymotrypsin and Fibrinolytic En
Transport Package
Depend on Customer Request
Specification
100g /500g
Trademark
Bolai
Origin
China

Product Description

 

Aprotinin CAS NO: 9087-70-1


Aprotinase, also known as Bovine pancreatic trypsin inhibitor BPTI, Kallikrein inhibitor, etc. Its molecular formula is C284H432N84O79S7, which is a basic polypeptide chain containing 58 amino acid residues. Its molecular weight is 6.5KD(6511.44), and its isoelectric point is 10.5.
 
Aprotinin is a white or yellowish powder, odorless, soluble in water, soluble in 70% ethanol and 50% acetone, has dialysability.

Aprotinin is an inhibitor of serine protease, and its preparation is mainly used for the treatment and prevention of pancreatitis; For the treatment of acute bleeding; For antishock; It is used to prevent intestinal adhesion.

This product is extracted from the lung of yellow cattle. The crude product of aprotinin is obtained by acid water extraction and ammonium sulfate precipitation. The crude product then goes through acid precipitation, filtration, chromatography purification, sterilization and freeze-drying to obtain aprotinin freeze-dried powder products.
 
Test Items Specifications Results
Appearance Almost white powder; hygroscopic Conform
Solubility Soluble in water and 0.9% NaCI solution practically insoluble in organic solvents Conform
Appearance of solution clear Conform
Absorbance A0.80(absoption-max.:277nm±2nm;3.0 Ph.Eur.U./ml) 0.76
Identification A Positive Conform
Identification B Positive Conform
Aprotinin oligomers Maximum1.0% 0.3%
Pyroglutamyl-aprotinin
and related compounds
Pyroglutamyl-aprotinin max.1.0% 0.03%
Any other impurity max. 0.5% 0.3%
Sum of impurity other than pyroglutamyl-aprotinin max.1.0% 0.5%
Des-Ala-Aprotinin  And des-Ala-des-Gly-aprotinin impurity A:maximum 8.0 per cent 6.38%
impurity B:maximum 7.5 per cent
 
6.98%
pH 5.5-7.0 6.2
Loss on drying 6.0% 5.5%
Bacterial endotoxins ≤ 0.14 EU / Ph.Eur.U. Conform
Abnormal toxicity Non toxic at 2 Ph.Eur.U. / 0.5ml Conform
Histamine 0.2ug histamine base/3 Ph.Eur.U. Conform
Microbial Limit TAMC And TYMC :≤102 in total CFU/g API Conform
Staphylococcus aureus, Pseudomonas areuginsosa, Escherichia coli, should be absent per 1 g(ml), Entrobacteria, resistant to bile, should be absent per 1 g(ml) Conform
Activity 3.0 Ph.Eur.U./mg 3.67EPU/m (6620KIU/mg)
Conclusion Comply with EP 9.0

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