| Customization: | Available |
|---|---|
| Varieties: | Infectious Disease Prevention Medicine |
| Component: | Chemical Synthetic Drugs |
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| 10% coated enrofloxacin premix Veterinary use only Product name : enrofloxacin premix Main composition: enrofloxacin Character: a kind of white granule Pharmacologic action: pharmacodynamics, Well belongs to the animal characters and the appropriation of sterilization broad spectrum antimicrobial agents, for e. coli, salmonella, klebsiella bacillus, brucella, pasteurella, pleuropneumonia actinobacillus, erysipelas, bacillus proteus, clayey Mr Charest's bacteria, suppurative corynebacterium, losing blood pott's bacteria, staphylococcus aureus, mycoplasma, chlamydia, etc all have good effect, less effect on pseudomonas aeruginosa, streptococcus, weak effect on anaerobic bacteria. It has obvious antibacterial effect on sensitive bacteria. The antibacterial mechanism of this class of drugs is applied to bacterial cell DNA gyrase ( topology isomerase), interfere with the bacterial DNA replication, transcription and repair the restructuring, the bacteria will not grow properly and death. Its effect is obviously concentration-dependent, and the best therapeutic effect can be achieved when the serum concentration is greater than 8 times MIC. pharmacokinetics, Most animals with a single stomach can be absorbed very well. The concentration of blood drug reaches the peak within 0.5 ~ 2 hours. The food in the stomach can delay the rate of drug absorption, but the absorption quantity is not affected. This product is widely distributed in animals, and can enter tissues and body fluids (including bones and prostate) very well. Except that the concentration of cerebrospinal fluid is only 6% ~ 10% of the serum concentration, the drug concentration in almost all tissues is higher than that in plasma, and it can accumulate up to 140 times of the plasma concentration in white blood cells. The hepatic metabolism was mainly the formation of ciprofloxacin from the ethyl group of 7-piperazine, followed by oxidation and glucuronic acid binding. Elimination is mainly through the kidney (renal tubular secretion and glomerular filtration) excretion, 15% ~ 50% in the original form from the urine excretion. Drug interactions: (1)It has synergistic effect with aminoglycosides and broad-spectrum penicillin. (2) Ca2+, Mg2+, Fe3+, Al3+ and other heavy metal ions can chelate with this product, affecting absorption. (3) with theophylline, coffee can make the latter because of combined metabolic inhibition, the concentration of theophylline, caffeine in the blood abnormal increase, even theophylline poisoning symptoms. (4) have inhibition of liver drug enzyme effect, and in the liver metabolism of drugs used together, can make its clearance rate decreased, blood drug concentration increased. (5) propanesol can inhibit the secretion and excretion of its renal tubules, and prolong its half-life. Indication : Fluoroquinolone antibiotics. Used for bacterial diseases and mycoplasma infections Usage and dosage: Mixed with feed, each 1000kg feed with 1kg , for 7 days Adverse reaction: (1) it can denature the cartilage of young animals and cause claudication and pain. (2) the digestive system reacts with vomiting, abdominal pain and abdominal distension. (3) skin reactions include erythema, pruritus, urticaria and photosensitivity Specification : 10% Package: 1kg/bag Shelf life: 2 years Storage : seal well and keep in dark dry place |
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